拇山生物醫學研究講座
Moon-Shan biomedical research forum
本所訂於二月二十二日(二) 假醫學綜合大樓前棟四樓誠樸廳舉辦『拇山生物醫學研究講座』,敬備茶水(請自備杯子),歡迎全校師生踴躍出席!
主題:
Topic
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Chromatin remodeling genes in gynecologic cancer progression and therapy
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演講者:
Speaker
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施益民 教授 Ie-Ming Shih, M.D., Ph.D.
Richard W. TeLinde Distinguished Professor
Director, TeLinde Gynecologic Disease Program
Co-Director, Women's Malignancies Program
Johns Hopkins University School of Medicine
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時間:
Date
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111年2月22日(二) 上午10:00~12:00
February 22, 2022, 10:00-12:00
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地點:
Venue
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醫學綜合大樓前棟四樓誠樸廳
4F Hall, Comprehensive Medical Building (Front Building)
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語言:
Language
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中文 Chinese
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主辦單位:
Organizer
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醫學科學研究所
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Abstract:
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of cancers, especially in those gynecologic cancers arising from ectopic or eutopic endometrium including ovarian clear cell, ovarian endometrioid and uterine endometrioid carcinomas. As a subunit of SWI/SNF chromatin remodeler, ARID1A facilitates target-specific binding of SWI/SNF complexes to chromatin, thereby altering the accessibility of chromatin to a variety of nuclear factors. In human cancer, ARID1A possesses not only features of a gatekeeper, regulating cell cycle progression, but also features of a caretaker, preventing genomic instability through DNA damage repair. Moreover, an increasing body of evidence suggests that ARID1A containing SWI/SNF complexes play a pivotal role in transcriptional regulation of genes involving in several cancer-associated signaling pathways. In this seminar, we will discuss the mechanisms underlying how ARID1A mutations cause cancer progression and the clinical implications of synthetic lethality in developing ARID1A mutation-based therapeutics.
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請登入「人才發展系統」https://ehrd.tmu.edu.tw/eHRD/eHRDOrg → (左上方) 查詢與申請→ 課程「醫科所【拇山生物醫學研究講座】- 111/02/22 演講者:施益民 教授 (Johns Hopkins University School of Medicine)」(「關鍵字」可以搜尋:拇山 ) →教室→確認
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